It usually takes 5.5 half-lives for a drug to be completely eliminated from the system. This means that CBD taken orally would be completely out of the body in around 11 to 28 days, although it may be impossible to detect it in a blood test much earlier. The half-life of vaporized or smoked CBD in blood plasma is much shorter than that of CBD ingested within a few hours. Regular users may take longer to completely remove CBD from their system than occasional or new users. In short, CBD oil can stay in your system between 4 and 25 days.
This is an extensive amount of time, but it is currently the most accurate estimate that scientists have made so far. CBD inhalation has been shown to have fast absorption rates since the lungs transfer CBD directly into the bloodstream. When CBD or any other drug is taken directly into the vein, the bioavailability of the drug is assumed to be 100%.A study conducted on healthy male subjects showed that inducers of CYP3A4, an enzyme involved in the metabolism of CBD, significantly reduced the maximum plasma concentration of CBD. The highest bioavailability (how much is absorbed and enters the bloodstream) comes from CBD that is vaporized or smoked, and CBD oil tinctures applied sublingually (under the tongue) come in second place.
With sublingual consumption, CBD is placed under the tongue and transferred to the bloodstream through the mucous membranes and capillaries in the mouth, effectively bypassing the digestive system and liver. It is a misconception that CBD could appear in a drug test. Single-use CBD doesn't stay in your system for more than a week, even if taken at the highest dose. The effects of CBD usually wear off within a few hours, but this depends on the amount of CBD taken, the method used, and the user's size, metabolism, and usage history. The strictly topical application of CBD works locally; the applied CBD product never reaches the bloodstream. The amount of CBD that remains in your system after a dose depends on several factors, including the method of consumption, dose and frequency of use, and use of other medications.
In some cases of intensive use, CBD can remain in the system for up to a week and detection periods extend to more than a month. CBD (or cannabidiol) is stored in fat cells and can remain detectable for days or even weeks in a blood test. Hemp products are legal in all 50 states and should not test positive for THC as long as they have been tested in a third-party laboratory for CBD content. When applied topically, CBD is expected to enter the skin via the transfollicular route and accumulate in the sebaceous gland.
